Publications

Lian F, Smith D, Ernst H, Russell RM, Wang X-D. Lycopene metabolites, apo-10'-lycopenoic acid, inhibits the growth of lung cancer cells in vitro and suppresses lung carcinogenesis in A/J mice in vivo. Carcinogenesis 28, 1567-1574, 2007.

Mernitz H, Smith D, Wood R, Russell RM, and Wang X-D. Inhibition of Lung Carcinogenesis by 1alpha,25-Dihydroxyvitamin D3 and 9-cis Retinoic Acid in the A/J Mouse Model: Evidence of Retinoid Antagonism of Vitamin D Toxicity. International Journal of Cancer 120, 1402-1409, 2007.

Kim Y, Lian F, Yeum KJ, Russell RM, and Wang X-D. The Effects of Combined Antioxidant (beta-Carotene, alpha-Tocopherol and Ascorbic acid) Supplementation on Antioxidant Capacity, DNA Single-Strand Break and Regulation of Insulin Growth Factor-1/IGF-Binding Protein 3 in Ferret Model of Lung Cancer. International Journal of Cancer 120, 1847-1854, 2007.

Mernitz H and Wang X-D. The bioconversion of carotenoids into retinoids: Implications for cancer prevention. In: "Vitamin A: New Research"ed. Loessing, I. T. Hauppauge, NY: Nova Science Publisher, Inc. press, pp 1-19, 2007.

Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM and Wang X-D. The Biochemical Characterization of Ferret Carotene-9', 10'-Monooxygenase Catalyzing Cleavage of Carotenoids in vitro and in vivo. J Bio Chem 281; 28:19327-19338, 2006.

Kim Y, Liu XL, Liu C, Smith DE, Russell RM, Wang X-D. Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone: A model for human lung cancer. Cancer Letters 234: 209-219; 2006.

Taparia S, Fleet JC, Peng JB, Wang X-D, Wood RJ. 1,25-Dihydroxyvitamin D and 25-Hydroxyvitamin D-mediated Regulation of TRPV6 (a putative epithelial calcium channel) mRNA Expression in Caco-2 Cells. Eur J Nutr 45: 196-204, 2006.

Liu C, Russell RM, Wang X-D. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets. J Nutr 136: 106-111, 2006.

Kim Y, Chongyviriyaphan N, Liu C, Russell RM, Wang X-D. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis 27; 1410-1419, 2006.

Lian F, Hu KQ, Russell RM, Wang X-D. Beta-Cryptoxanthin inhibits the growth of immortalized human bronchia epithelial cells and non-small cell lung cancer cells and up-regulates retinoic acid receptor Beta expression. International J Cancer 119, 2084-2089, 2006.

Mernitz H, Smith D, Zhu AX, Wang X-D. Effects of 9-cis retinoic acid supplementation on COX-2 and RAR beta levels and tumor formation in the lungs of NNK-induced A/J mice. Cancer Letters 244; 101-108, 2006.

Wang X-D and Stace King. Effect of carotenoids on signal transduction pathways: Significance in lung cancer prevention. In: "Nutrients and Genes Interaction in Cancer' ed(s). Friso and Choi. Boca Raton, FL: CRC. press, pp 113-128, 2006.

Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang X-D, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinoid metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J 19: 845-847, 2005.

Wang X-D. Biological activity of lycopene against lung cancer: Targeting IGF-I/IGFBP-3 signal transduction pathway. In: "Carotenoids and Retinoids: Molecular aspects and Health issues" ed(s). Packer, Obermueller-Jevic, Kraemer and Sies. Champaign, IL: AOCS. press, pp 168-181, 2005.

Wang X-D. Alcohol, Vitamin A and Cancer. Alcohol 35: 251-258, 2005.